Quantitative assessment of retinal thickness and vessel density using optical coherence tomography angiography in patients with Alzheimer’s disease and glaucoma

Purpose Assessment and a direct comparison of retinal vessel density with the thickness inner layer (IRL) outer (ORL) in same regions macula subjects Alzheimer’s disease (AD) primary open-angle glaucoma (POAG). Methods We analyzed data from 48 eyes healthy control (HC) participants, 71 POAG, 49 AD patients. Ophthalmic examination included optical coherence tomography (OCT) imaging to measure IRL ORL OCT angiography (OCTA) region for superficial vascular plexus (SVP) deep (DVP) retina. A layers thickness, which different dynamic ranges, was obtained by normalizing values as percentage losses. Results Patients presented significantly greater losses DVP compared POAG (p <0.001), but SVP were considerable (p<0.001). Positive associations among presence observed primarily retina where 1% decrease associated about 24–29% increase odds AD. According OCTA measurements, positively 4–9% In positive only loss 13–23% risk disease. Conclusions Analysis could potentially improve diagnostic capabilities may provide valuable approach predicting